Fire crews responded to the fire in the 8100-block of South Maryland Avenue shortly before 6:30 p.m. The blaze was in a three-story home.
All three people found were treated and released.
The fire was struck out around 7:15 p.m. A fourth person who firefighters had been searching for was accounted for at his job, fire officials said. No details have been released about the cause of the fire.