Europe's losses echoed those in Asia. Japan's Nikkei 225 stock average fell for the first time in three days, dropping 631.56 points, or 6.79 percent, to 8,674.69, while Hong Kong's Hang Seng sank 5.2 percent and South Korea's main index shed 5.1 percent.
U.S. stocks are also expected to drop again when Wall Street opens. Dow Jones industrial average futures fell 126, or 1.4 percent, to 8,909. On Tuesday, the Dow retreated 231 points after a host of companies such as chemical manufacturer DuPont Co., Sun Microsystems and Caterpillar Inc., downplayed their prospects for the coming months.
"Wall Street tumbled before the close last night and then with Yahoo! posting some poor Q3 numbers, this is certainly the sort of news that is setting the mood right now," said Matt Buckland, a dealer at CMC Markets.
All eyes will be on earnings updates in the U.S. later. Among the companies reporting Wednesday are Amazon.com Inc., AT&T Inc., Boeing Co., McDonald's Corp. and Merck & Co.
Fears about the economic outlook have become the markets' primary concern as worries over the banking system have been assuaged, for now at least, by concerted government attempts to shore up banks, as well as massive liquidity boosts from the world's leading central banks.
Commodity stocks have been particularly hit in Europe. Mining company BHP Billiton PLC was down more than 9 percent after it warned of uncertain economic conditions in China, the main driver of global economic growth in recent years. Another major mining firm, Anglo American PLC, was also down over 6 percent following BHP's warning.
"It's not a good day for commodity stocks and they're dragging the indexes down," said David Jones, chief markets strategist at IG Index.
Oil stocks were also weighed down by another $2.50 fall in oil prices to $69.67 a barrel despite expectations that the OPEC oil cartel will cut production later this week in an attempt to shore up prices, which have fallen by 50 percent in just three months.
The biggest oil loser was Spain's Repsol YPF SA, which was down 14 percent, over mounting concerns about the state of the Argentine economy. Argentina's President Cristina Fernandez proposed on Tuesday that the government take over nearly $30 billion in private pension funds, saying retirees must be protected from the global financial crisis. Her move spooked investors and triggered steep falls in Argentine stocks and bonds. Repsol has a large bulk of its business in South America.
Some relief to the growing earnings gloom has been provided by the continuing fall in interbank lending rates. The rate on three-month loans in dollars, known as the London Interbank Offered Rate or Libor, has fallen sharply, by 0.29 percentage point, to 3.54 percent, while the so-called European Interbank Offered Rate for three-month euro-denominated loans has fallen 0.03 percentage point to 4.936 percent, the lowest rate since June 5.
Abnormally high interbank lending rates have been the catalyst for the crisis in the financial markets over recent weeks, raising fears they would choke off credit to businesses and individuals.
Earlier, Asian markets suffered as markets fretted about the profit outlook ahead. Particularly hard hit were Japan's megabanks, which slumped after The Nikkei financial daily reported that Mitsubishi UFJ would miss its net profit projection for the April-September period by about two-thirds due to higher bad loan costs and the falling value of its shareholdings.
A stronger yen added to the misery in Japan, dragging down exporters such as automakers and consumer electronics firms. A stronger yen reduces the value of overseas profits when repatriated to Japan. Sony Corp. plunged 9.3 percent, Canon Inc. was off 6.1 percent and Panasonic Corp. stumbled 8.4 percent.
In Hong Kong, conglomerate Citic Pacific Ltd. plunged another 25 percent as local securities regulators announced a formal investigation into the company. Shares in the the firm, the Hong Kong arm of the Chinese government's main investment company, crashed more than 55 percent in the prior session after it revealed HK$15.5 billion (nearly $2 billion) in possible losses due to unauthorized currency bets made by a top executive.
In China, the benchmark Shanghai Composite Index fell 3.2 percent to 1,895.82.
In the currency markets, the euro was down to near two-year lows below $1.30, while the British pound slumped to near five-year lows around US1.63 after Bank of England governor Mervyn King hinted at further rate cuts to come.
AP Writers Tomoko A. Hosaka in Tokyo and Business Writer Jeremiah Marquez in Hong Kong contributed to this report.