The blaze began on the first floor and spread up interior walls to the second floor, officials said.
According to authorities, a battalion chief on the scene rescued two teenage who were trapped inside a second-floor bedroom. The chief saw the teens through a window, then kicked in a door, took the two out and led them down to safety via a smoke-filled stairway.
The two teens were not injured. The still-and-box alarm fire was extinguished by 2:40 a.m.
The cause of the fire is under investigation.
(The Sun-Times News Group contributed to this report.)