Two others were injured in the crash that happened about 3:00 a.m. near West Monroe Street and South Pulaski.
According to Fire Media Affairs spokesman Joe Roccasalva, three people were traveling in the vehicle when it struck a pole, rolled over, and burst into flames.
"This car ...was coming down Pulaski real fast. And then it tried to swerve over and go around another car, and it lost control and went up on the sidewalk and hit the pole. Then it turned around from hitting the pole and hit the fire hydrant and flipped over," said Archie Collins, a witness on the scene.
Collins, along with eyewitness Patricia Hilliard, leaped into action to help the three people inside the burning vehicle.
"They were in very bad shape," Hilliard said. "They were bleeding out the mouth, nose, there was blood everywhere. I was trying to give them CPR, pumped them."
The bystanders managed to rescue two people from the fiery car.
One female passenger who became trapped inside the vehicle died at the scene, according to Roccasalva.
The two rescued victims were hospitalized in critical condition.