The SUV was driven by a 65-year-old man who was seriuosly injured. His 63-year-old female passenger was pronounced dead at the scene.
Two 19-year-old men in the minivan were hurt. Both had to be extricated after their vehicle rolled over.
The crash occurred at Route 83 and Riverside Drive around 3:30 p.m. Wednesday. Three ambulances responded to the scene.
All four people involved in the accident were wearing seatbelts, police say.
Anyone who may have witnessed the accident is asked to contact Villa Park police.