Workshops will be free and open to the public.
Issues will include the recession's impact on Hispanics, health needs, the housing downturn, education problems and citizenship.
"We're expecting at least 25,000 to 30,000 folks to participate in our conference. And again, we hope that that economic impact will be quite beneficial to the Chicagoland area," said Janet Murguia, La Raza president and CEO.
Mayor Daley and a member of President Obama's administration are among officials who will address the conference.