Crews will be shooting on the Michigan Avenue Bridge above the Chicago River, as well as aerial stunts near Trump Tower.
On Tuesday, city officials discussed the closures for July 15-18.
"Michigan Avenue will be closed between Ontario Street and Randolph Street starting 8 p.m. Thursday July 15th, and that will continue through 5 a.m. Monday, July 19," said Bobby Ware, Chicago Dept. of Transportation.
Lower Michigan Avenue will be closed between Hubbard and Wacker from 8 p.m. Friday to 5 a.m. Monday. Filming will also affect some downtown bus routes.
Last weekend, crews shot part of the movie in Chicago's Loop. Then they headed north to Milwaukee, Wisconsin, where shooting took place near the Milwaukee Art Museum.
The Transformers movies are known for their aliens and special effects. The specifics are being kept under wraps, but fans in Milwaukee said they saw posters of automobiles and a classic car on site.