The victim has been identified as 29-year-old Reggie Coles of Chicago.
There was no word Saturday evening of any suspects or a possible motive.
Police say at least a dozen other people were injured in shootings overnight.
Friday night an 18-year-old man was shot after boarding a Pace bus in Chicago's Gresham neighborhood near 79th Street and Western. Police say the victim was involved in an altercation outside the bus and after he boarded the bus. Another person reportedly followed him on and shot him.
The victim was shot in the leg and was taken to a hospital. Police say they have a person of interest in custody.