The drugs in question are Avandia and Actos.
New research finds the two diabetes drugs may raise the risk of broken bones in postmenopausal women with type-2 diabetes.
There was also a fracture risk seen among men who had been prescribed either Avandia or Actos plus a loop diuretic.
This isn't the first time such an association has been seen. It's raising doubts as to whether these drugs should be the first choice for treating type-2 diabetes.
Earlier this summer an FDA advisory concluded that Avandia raises the risk of heart attack and should only stay on the market with tightened controls.
The latest research appears in the Journal of Clinical Endocrinology and Metabolism.