The incident took place around 1:15 a.m. outside a party in Garfield Park.
Police say multiple gunmen in a black Cadillac opened fire after a fight broke out.
A 23-year-old was shot in the thigh and back and a 20-year-old was shot in the thighs, stomach and hip, Bay said. They were both taken to Mount Sinai Hospital where they were listed in guarded condition.
Two other 20-year-old women were shot -- one with a graze wound to the left thigh and one in the back of the neck, police said. They were treated and released at Norwegian-American Hospital.
The Sun-Times Media Wire contributed to this report.