The truck turned over at approximately 2:30 a.m. on the ramp from northbound LaGrange to the outbound Stevenson.
The driver was ticketed following the crash, state police said.
The semi truck hauling a trailer lost control at the bottom of the ramp and rolled onto the driver's side, State Police District Chicago Master Sergeant Joe Stangl said.
The semi was carrying a load of boxes of stuffing when the trailer split. So, crews brought in another semi to offload all of the first truck's contents. The clean-up process took hours as crews continued to make the transfer. A third truck was also brought to the scene to help.
Drivers staring at the accident caused traffic to back up on the inbound side of the Stevenson, as well. The jam reached all the way to the Tri-state and beyond at one point.
The semi's driver reportedly managed to crawl out of the truck on his own and was taken to Adventist LaGrange Memorial Hospital in LaGrange with minor injuries.
He was also cited for driving too fast for conditions, Stangl said. His identity was not immediately available.
State police say they are investigating.
(The Sun-Times Media Wire contributed to this report.)
