The former Illinois governor told the Associated Press he would never admit to "things that are false and not true."
He faces a number of charges, including allegations he tried to sell or trade President Barack Obama's former senate seat.
A trial last year ended with jurors deadlocked on 23 of 24 counts against him. Jury selection for his second trial is set to begin on Wednesday.
Blagojevich said he's talked to his daughters about the possibility he could go to prison and has assured them no matter what happens they'll be fine.