She received 58 percent of the vote to easily lead the 10-candidate field in Tuesday's voting in the heavily Democratic city.
Freeman-Wilson got a boost last month when current mayor Rudy Clay quit the race to battle prostate cancer. Clay endorsed her.
Finishing second was City Councilwoman Ragen Hatcher.
If elected this November, Freeman-Wilson would become the first African-American woman to be mayor of an Indiana city.