This comes after a student, Katelyn Carlson, died in 2010 of a severe allergic reaction while at school.
Chicago Public Schools will now be stocked with four to six EpiPens.
Students will be able to carry and self-administer other asthma or allergy medication with permission from a parent along with a copy of their prescription.
The new policy includes a plan for handling students with Type 1 or Type 2 diabetes.