It happened around 7:15 a.m. near 67th and Halsted.
Police investigators say the driver of the car veered in front of the southbound Number 8 bus and hit it head on. A passenger inside the car was killed and the driver was seriously injured. None of the passengers on board the bus were hurt.
It's not clear what may have caused the driver to veer into oncoming traffic. The victim's identity has not been released by police.