The train was heading from Chicago to Port Huron, Michigan, when it hit a car near Lansing.
The driver of the car, who was the vehicle's only occupant, was killed; no one on the train was hurt -
Amtrak says buses took passengers to their destinations.
An Eaton County Central Dispatch operator says the crash happened about 9:10 p.m. Thursday in Eaton County's Delta Township.
There were about 145 passengers on board.
The Associated Press contributed to this report.
