It happened Saturday morning on Sibley Boulevard near the Bishop Ford Freeway in south suburban Dolton.
Investigators were on the scene for more than six hours after the accident as traffic was rerouted.
Dolton police say a black Ford SUV with a family of four inside had just pulled out from a side street and apparently failed to yield when it was struck by this silver Hyundai with just the driver inside.
The girl was thrown from the vehicle in her car seat. Witnesses said at least four or five people had to lift the vehicle off her.
"At first the the child was not breathing, and after I told the father to lay her down on the ground, she had a pulse," said witness Richard Warren. "It seems like she got her breathing back together."
"I have never seen nothing like it," said another witness, Chuck Vallo. "Definitely shocked me. Especially to see little kids involved in it."
ABC7 has learned the driver of the black SUV was 37-year-old Parris Williams, who works as a children's minister at Lilydale First Baptist Church on Chicago's far South Side.
The girl was initially taken to a hospital in Indiana before being airlifted to Comer. The four other people who are injured were also hospitalized. Police say those people are expected to survive.
Neighbors say the intersection where the accident occurred can be for drivers.
The stop sign is set back from the intersection and residents say trees can block the view of cars speeding over this hill.