According to witnesses, several people were waiting at the glass bus shelter when the accident happened at approximately 2:20 a.m. Saturday at Roosevelt Road and Independence Boulevard.
All five victims were taken to hospitals with a variety of injuries, however, none are life-threatening.
Chicago police says it all started around 2 a.m. when a Cadillac traveling at a high rate of speed struck a Grand Prix.
The impact caused the Grand Prix to slam into the bus shelter.
The drivers of both cars fled the scene on foot leaving behind their passengers. Two people were in the Cadillac. One person was in the Grand Prix.
Authorities say the incident remains under investigation.
(The Associated Press contributed to this report.)