It happened around 2 p.m. near Garfield and Ashland. One of the men was shot in the head and is listed in critical condition.
Witnesses said the shooting appeared to be related to a gang dispute.
The Rev. Mose Brown was upstairs at his New Beginnings Church preparing for the afternoon service when he heard a car come screeching to a stop. Moments later , he heard gunshots.
He walked outside to find four young men shot, one in the head.
"I began to pray because I knew there wasn't fireworks or nothing," Brown said. "I know this was a problem. I said, 'Oh lord, not again. Not again.' "
Witnesses say the gunman got out of the car and opened fire into a group of young men. One victim, shot in the leg, ran into a mobile phone store nearby to call for help.
Police said such scenes are all too common.
"They're just shooting everybody and it doesn't make any sense," said Jacqueline Wallace, who lives nearby. "I have been around this neighborhood for 40 years and it has been going on throughout, throughout, throughout."
None of the injuries are considered life threatening .