The separate incidents occurred Friday and Sunday mornings. The girl's death reportedly has shocked those in her Little Village neighborhood.
According to witnesses, Aliyah Shell was on her front porch with her parents Saturday afternoon in the 3100-block of South Springfield when a pickup truck pulled up and started shooting, hitting the little girl twice -- once in the chest.
The 6-year-old was taken to the hospital where she was pronounced dead.
A neighbor rushed to help the family when the shooting happened.
"I couldn't believe it. This guy had a cowboy hat on. It just looked like two normal guys who were saying hello or something. I just heard four gunshots and then a lot of screaming after that," said neighbor Reynaldo Navarro said. "Poor thing got hit, and she was still running around trying to get in the house. That's the thing that sticks out in my mind."
Some residents in the area say the shooting was gang-related.
Chicago police said they were questioning two people, but they were not calling them suspects early Sunday.
According to the Sun-Times Media Wire, at least six other people were killed, and 33 people were wounded in shootings in the city since Friday night.
Besides the death of the 6-year-old girl, this weekend's fatal shootings include:
Joel Sanroman, 42, who was driving in the 3100 block of West 53rd Street about 12:45 a.m. Saturday, when several males on the street started yelling gang slogans at his car and shot at him as he passed, police said. Sanroman, of the 5200 block of South Mozart Street, was shot in the head and pronounced dead at 1:02 a.m., according to the medical examiner's office.
Adrian Cruz, 24, who was standing in the 5900 block of South Fairfield Avenue, the block where he lived, about 7:04 p.m. when someone inside a vehicle fatally shot him. He suffered multiple gunshot wounds and was taken to Stroger Hospital, where he was pronounced dead at 8:17 p.m.
Vincent Fitts, 22, who was found at 7:50 p.m. with a gunshot wound to the head in the 800 block of East 79th Street. Fitts, of the 4100 block of West Cermak Road, was pronounced dead at the Stein Institute at 10:45 p.m.
Jeremy Anthony, 24, of the 6400 block of South Ellis Avenue, was shot in the back while inside a vehicle in the 6300 block of South Ellis Avenue about 10:30 p.m., police News Affairs Officer Amina Greer said. He may have driven himself to nearby University of Chicago Medical Center where he was dead upon arrival.
Bert Lindsey, 36, of the 7500 block of South Wolcott Avenue, was in the backyard at a party on that block about 1:20 a.m. Sunday when shots were fired into the yard from a passing vehicle. He suffered a gunshot wound to the abdomen and was pronounced dead at 2:16 a.m. at Advocate Christ Medical Center.
A man in his 20s was shot dead and two others wounded in a shooting in the 1400 block of West 53rd Street about 1:55 a.m. Sunday. Two people were taken to Stroger and one other was taken to Mount Sinai Hospital, police said. The man killed was in his 20s, according to the medical examiner's office, which said his family had not yet been notified as of about 10 a.m.
In other incident, police say a 17-year-old girl and 20-year-old woman were shot in the 7700-block of South Essex Avenue at approximately 5:30 pm. Friday. The girl was shot in the hand, and the woman suffered a graze wound to the nose. Both were treated at South Shore Hospital, police said.
Authorities also said one person was taken into custody for the shooting.
Police also said a 22-year-old man sitting on his front porch was shot in the chest about 9:28 p.m. in the 11800-block of South Sangamon Street.The victim was on the porch Friday night with a friend when they heard shots and he realized he was shot, police said. A relative drove the man to Roseland Community Hospital. He was transferred to Stroger Hospital in "stable" condition, according to authorities.
About 20 minutes later, police say a 19-year-old man was shot in the head in the 6300-block of North Oakley Avenue. The gunman called the man over to a vehicle before shooting him.
At approximately 10:10 p.m., a 40-year-old woman driving south was wounded in the buttock when a bullet came the door of her vehicle in the 1400-block of South Pulaski Road, police said.
In another incident, a 36-year-old man was driving east in the 2100-block of West Fletcher Street about 11:15 p.m. when shots were fired at his vehicle from a passing white pickup truck, according to police. He reportedly was taken in "stable" condition to Advocate Illinois Masonic Medical Center with a gunshot wound to the face.
Two men were standing in the 7400-block of South Blackstone Avenue about 1:20 a.m. Saturday when an unidentified gunman stepped from an alley and fired shots, police said. One of the men, 22, was shot in the chest and was at Stroger Hospital in good condition. The other man, 21, was at Jackson Park Hospital and Medical Center in good condition.
Saturday evening around 7:30 p.m., two men were wounded in a shooting on the Eisenhower Expressway near the 2900-block of West Congress Parkway, police said. One of the men, 37, reportedly was shot in the head and back. Information on the other wounded person was not immediately known. The fire department said it took two men from the scene to Mount Sinai Hospital in serious-to-critical condition.
About 9:05 p.m., a man and two teenage girls were standing on the sidewalk in the 8300 block of South Kedzie Avenue when several males fired shots, police said. One 14-year-old girl was shot in the left leg and the other girl, also 14, was shot in the right leg, police said. Both girls were taken in good condition to Advocate Christ Medical Center and Holy Cross Hospital. A man in his 20s was also shot in the chest and taken in serious condition to Stroger Hospital.
(The Sun-Time Media Wire contributed to this report.)