Authorities say two men walked into a convenience store in the 1400 block of West 79th Street at about 6 p.m. and shot six people. All of the victims are between 18 and 25 years old.
A 22-year-old man is dead, four are critical and one is in good condition.
Police say the gunmen drove away in a silver SUV.
Neighborhood pastor Londale McNeal says he saw a suspicious car outside the store and two masked men.
"I heard about 10-12 shots, and when I looked back I saw a gray vehicle sitting in front of the store, here and we see two guys jump into the car and speed off," said McNeal.
He ran inside after the car drove off.
"Some were on the floor, the other ones were scattering, trying to get out of the store. Because they were shot when I went in," McNeal said.
Pastor McNeal says he knew all of the victims and believes the shooting may have been gang-related.
Father Michael Pfleger of Saint Sabina Catholic Church hopes nearby cameras help catch the gunmen.
"Right across the street from this is a camera," he said. "Let's see if that camera is working and has information. It better have information in it and it better be working."
Father Pfleger says the violence in the neighborhood is unacceptable and hopes eyewitnesses come forward.
"There's massive traffic on 79th at 6 o'clock in the afternoon. A lot of people saw on the street saw it and people saw it in their cars. So people need to come forward now. If you really care about black kids getting shot, open your mouth," Pfleger.
No arrests have been made.