A man was shot in the shoulder in the 2400-block of North Cannon Dr. outside the Peggy Notebaert Nature Museum and a female was struck by a vehicle.
No further details about what happened were available early Saturday.
Two people were transported to Advocate Illinois Masonic Medical Center. A third person was taken to Northwestern Memorial Hospital.
It's not known how the third person was injured.
Police are investigating and no one is in custody.