Flames ripped through three homes in the 1900-block of West Larchmont Avenue in the North Center neighborhood.
Firefighters say the fire sparked at approximately 1 a.m., helped by the dry conditions caused by little rain in recent weeks.
According to fire officials, seven adults and three children are displaced. No injuries were reported.
One neighbor was waiting later Tuesday to get back into his home to see if anything could be salvaged.
" I heard all the noise in the neighborood, and I woke up and I ran...and looked up the stairs and fire. I couldn't get out that way. My bedroom is in the basement. So, I ran into the back of the house and went out the backdoor. It was devastating," homeowner Joe Jewell said.
Another unidentified man who was bowling nearby at the time saw the flames on his way home and rescued people from one of the homes.
"We jumped the gate, went inside, and we had two teams inside. And one of them came through the back to catch it from the back and make sure everyone was out of that building. The heat was so intense. The fire was just too much, but we made it happen," he said.
Firefighter were able to get the blaze extinguished. The cause of the fire is under investigation.