It happened at approximately 2:30 a.m. One witness told ABC7 Chicago she heard 17 gunshots.
Quiltavia Patterson, 25, and 38-year-old Jermaine Carter were killed. The two others, a man in his 40s and a woman in her 20s, were transported to hospitals with gunshot wounds and were said to be recovering. One other person was taken to a hospital after suffering another kind of medical emergency.
Family members mourned Patterson and Carver Tuesday, wondering why their loved ones were taken from them.
"She was a good person, a good mother, a good sister, my best friend," Patterson's sister Shantavia King said tearfully.
Patterson was the mother of 3-year-old twins, a University of Illinois at Urbana-Champaign graduate and an aspiring rapper. She was shot in the head.
"She took care of her kids, and she was all about family. That's really why she was here in Chicago, to see us, and her life got taken," King said.
"She was a beautiful person. She had twins. She didn't bother anybody. She just relocated to Springfield. She just was a fun person. She was never a troublemaker," mother Cynthia Patterson said.
Patterson lived in Springfield with her children and was in Chicago visiting family. Relatives say they are not sure why she was in the area of the shooting.
"Everyone that was there was just minding their own business. I don't understand why they need to be victims of something like this. They leave behind their families and their friends, and now, everyone suffers from it," friend Diana Wackrow said.
Jermaine Carter was a husband and father of two children. The tattoo artist also known as "Face" was well known in the West Pullman neighborhood. His wife says he was talking to friends outside of the home and asking people sleeping in a car if they needed help when the bullets started flying.
"He was a nice guy, a kind person, kind-hearted, and he is just willing to help anybody. You know, the type of person that is just so friendly with everybody and calls people his friends that he didn't even know for a week. I'm just the opposite, but he had a heart, a big heart," wife Valerie Simms Carter said.
"He was a nice person, and that's all I can say. He was a nice person. They always take the good ones," Carter's friend Billie Jo Clayton said. "My friend, Stephanie, just called me at 5:30 in the morning, woke me up, told me they got him."
Chicago police remained on the scene for several hours, even blocking off some side streets.
Chicago police said they were looking for a dark-colored SUV and one or two shooters. It was unclear whether more people were also inside the car.
A $1,000 reward is being offered by the group No Guns No Violence.