The crash happened at approximately 6 a.m., shutting down the expressway for several hours and causing major traffic delays. All lanes were reopened by noon.
Police say a 29-year-old woman was dead at the scene. Her identity has not yet been released pending family notification.
Three others were taken to Chicago-area hospitals in critical condition.
Illinois state police say at least two -- possibly four-- cars were involved. Chicago Fire Department officials confirmed one woman was dead.
During the expressway closure, traffic in the inbound lanes was being diverted onto Cicero Avenue.
The cause of the crash was under investigation.