The crash happened around 9 p.m. Friday night between Hanford and Selma on Highway 43 near Cairo Avenue.
The California Highway Patrol says Victoria Robinson was driving south in the northbound lanes of the highway when she crashed into three other vehicles.
Other drivers stopped and pulled the victims out of the wreckage just before three of the cars caught on fire.
31-year-old Arthur Lara and another unknown driver died. Lara's family members tell us his three-year-old son was injured in the crash and is now recovering from surgery.
Authorities say Robinson is in fair condition and will be booked for vehicular manslaughter and DUI.