The group created a temporary garden of giant paper flowers to symbolize the schools that will be shut down.
The CPS school board voted last week to close 49 elementary schools and one high school because of falling enrollment.
"They are deceiving us one more time. Rahm Emanuel is in office right now because we trusted Barack Obama, because he threw him at us and we did not fight,"
"I just feel angry and sad and don't want it to close down," said Vega's daughter Meleny Ramos.
Organizers are having parents sign letters that will be sent to elected officials.
"We need to stand together. In the CPS, all of our schools are going to be hurt by this," said organizer Cassandra Creswell.
"I'm here because I know that struggle. I know that feeling, and to show solidarity for the rest of the schools that are closing," said parent Sherice McDaniel, whose school building was saved.
Protesters say more than 40,000 students will be affected by the closings, and that everyone in Chicago will be impacted by the closings.