Santa Monica police Sgt. Rudy Flores several victims are down and the shooter is also believed to be down.
Flores says numerous witness called to report a man on a street corner shooting at vehicles including a bus.
The location is about three miles from where President Barack Obama is appearing at a fundraiser.
Santa Monica College is a two-year college with about 34,000 students. The campus in the coastal Los Angeles suburb spreads out over 38 acres.
