The woman, in her 30s, was thrown from the eastbound motorcycle when the driver careened into the divider near Pennsylvania Avenue just after 1 a.m.
She was thrown into the westbound lanes, where she was struck by a passing yellow cab. The taxi did not stop at the scene.
The woman was rushed to Brookdale University Hospital, where she was pronounced dead.
The driver of the motorcycle was not seriously hurt.
Investigators are looking into whether speed was a factor in the crash.