Police say all of the victims are in their 20's, and all were shot in the torso.
The gunfire broke out at about 1:30 a.m. at 395 East 48th Street.
Two of the victims were taken to Brookdale Hospital, and the others were transported to Kings County Hospital.
All of the injuries are described as non life-threatening.
Police are trying to determine whether the men were attending the party or were outsiders.
The NYPD is searching for suspects in the shooting.