Claire Weber was in Boston as the casket arrived. Her brother, Norman Dufresne, was reported missing in action in 1950 while serving in the Korean War.
Dental records and other evidence were recently used to identify his remains.
Weber says they all prayed so hard for him to come home.
He will be laid to rest with other family members in Massachusetts instead of Arlington National Cemetery.
"The last of the 12, the 12 of my family and I was here to see my kid brother come home. Finally after 63 years. Could you imagine?" said Claire Weber, sister.
People lined the streets as Dufresne's remains were returned to his hometown.
They will be buried this weekend.