The crash involving a semi truck and three cars occurred shortly after 5 a.m. near 85th Street, and lanes were reopened at 10:12 a.m., authorities said.
Three people were taken to Northwestern Memorial Hospital and another to Comer Children's Hospital after the crash, according to Fire Media Affairs.
One of the victims, a woman in her 30s, later died.
Illinois State Police are investigating, but weather is believed to be the cause after the semi jackknifed.
The Sun-Times Media Wire contributed to this report.
