A statue honoring the victims was unveiled Saturday near the Loomis Street Crossing.
It was on April 25, 1946, when a train slammed into the back of another train that was sitting on the tracks.
Many of the passengers were returning from World War II.
Organizers say the sculpture is made up of thousands of railroad spikes.
It depicts a factory worker and a sailor forming a human chain to help an injured passenger.
Several relatives of the victims were at the ceremony.