The rapper won for his album, "Coloring Book," beating out several established performers, including Drake and Kanye West.
Chicago Mayor Rahm Emanuel tweeted words of encouragement for local artists before the winners were announced.
Good luck to all Chicago artists who are up for #GRAMMYs tonight! The whole city is behind you.— ChicagosMayor (@ChicagosMayor) February 13, 2017
Another Chicagoan who took home not one, but two Grammys. Singer Lalah Hathaway won Best Traditional R&B Performance for "Angel." She also won Best R&B Album for "Lalah Hathaway Live." In that category, she beat out another Chicagoan, BJ the Chicago Kid, who was nominated for "In My Mind."
Earlier, during a non-televised part of the awards ceremony, Chance the Rappper also won a Grammy for best rap performance.
He had no prepared remarks as he accepted the award for Best Rap Album, adding that he didn't expect to win in this category.
But his acceptance speech was just as exuberant as the one for Best New Artist, during which he thanked God and his hometown of Chicago. Emanuel sent a follow-up tweet after Chance's win:
Rolling Stone magazine pointed out on Twitter that Chance was the first African American hip-hop artist to win the award in nearly two decades.
Chance the Rapper is the first black hip-hop artist to win #GRAMMYs Best New Artist since Lauryn Hill in 1999— Rolling Stone (@RollingStone) February 13, 2017
Chicago Cubs first baseman Anthony Rizzo attended the Grammys. He tweeted a picture of himself with his girlfriend, Emily Vakos, before the show and a photo with Chance.