The two-engine Piper Cheyenne crashed about 1 mile from the Lafayette Regional Airport, Federal Aviation Administration spokesman Tony Molinaro said.
Witnesses said the plane made contact with power lines and hit a parking lot outside a post office, blowing out the building's windows, before coming to rest in a field.
The plane was en route to a college football playoff game in Atlanta between Louisiana State University and Oklahoma, said Steven Ensminger Jr., who told The Associated Press that his wife, Carley McCord, was on board. Ensminger Jr. is the son of the offensive coordinator for the LSU football team. McCord was a sports reporter for WDSU-TV, the NBC affiliate in New Orleans.
The other passengers of the plane have been confirmed as follows:
Ian E. Biggs, age 51
Robert Vaughn Crisp II, age 59
Gretchen D. Vincent, age 51
Michael Walker Vincent, age 15
Stephen Wade Berzas, age 37, survived the crash and was listed in critical condition.
The victims of the Lafayette, Louisiana plane crash
Video and photos showed a trail of scorched and burning grass around the crash site in the city of Lafayette. A blackened car sat in the post office parking lot, which was carpeted with scattered tree limbs.
Four people were brought to the hospital: one from the plane, one on the ground and two post office employees who were brought in for evaluation, said Lafayette Fire Department spokesman Alton Trahan.
The aircraft was an eight-passenger plane, Lafayette Fire Chief Robert Benoit said.
The plane went down in a part of the city with a scattering of banks, fast food chains and other businesses.
Marty Brady, 22, said the lights went out at his apartment a couple of hundred yards or so away from the crash site as he was preparing to make coffee.
He said he ran out and saw black smoke and flames from the post office parking lot and downed power lines.
"There were some people screaming and somebody yelled that it was a plane," he said.
Brady said power line over the gate to his apartment complex was clipped by the plane.
"If it had been a little lower, it could have been a lot worse," he said.
Kevin Jackson told KLFY-TV he heard a "massive explosion" and saw a "big old ball of flame" when the plane crashed. He and other eyewitnesses told the TV station that the plane hit a car as it fell, and that someone could be heard screaming inside the vehicle.
Lafayette is the fourth-largest city in Louisiana with a population of about 130,000, according to the 2018 census. It is located about 135 miles west of New Orleans.