ABC7 gathered drone video and photos at some of the spots that are usually filled with tourists and commuters to find them all eerily empty.
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Only a few joggers and police officers are at popular tourist destinations like the Bean, Millennium and Grant Parks, the lakefront, Museum Campus, and the Chicago Theater.
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Meanwhile, some of the highest traffic CTA stations are also nearly empty, as more and more workers in the Loop telecommute and work from home.
Illinois Governor JB Pritzker issued a "stay-at-home" order for all Illinois residents Friday afternoon in an attempt to limit the spread of COVID-19 in the state.
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The Illinois Department of Public Health has created a hotline at 1-800-889-3931. More information can be found at the IDPH website and the Chicago Department of Public Health website.