At about 10:40 p.m., deputies with the Harris County Sheriff's Office responded to an in-progress shooting call in the 16000 block of 1st Street in Channelview.
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Upon arrival, deputies said they located two men with apparent gunshot wounds on the lawn along the side of a residence.
Both men were pronounced dead at the scene by paramedics, according to Sheriff Ed Gonzalez.
Investigators said the two men and a third unidentified suspect were armed and wearing masks during an "attempt to force entry" into the home.
A woman, a 12-year-old boy and two 17-year-old boys were inside the home during the attempted home invasion but were not injured, according to Gonzalez.
Deputies said one of the 17-year-olds retrieved a shotgun and discharged it several times, striking the two intruders.
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The third suspect fled the scene in an unidentified, dark-colored 4-door sedan.
There were no other reported injuries.
An investigation into the incident was ongoing.