The limited-edition line features Mrs. Which, Mrs. Who, and Mrs. Whatsit, three "powerful warriors made of stardust" who guide Meg Murry (portrayed in the film by Storm Reed) on a journey across the universe to find her missing father.
The dolls, which are available now for pre-order ahead of their Feb. 23 release, were designed by Carlyle Nuera.
Director Ava DuVernay - who herself was also featured on a Barbie doll in 2015 - posted a photo of the dolls to her social media accounts with a poignant message about representation.
[Ads /]
"When Disney makes Barbies of your movie's characters and you just want to stare at them all day in disbelief because you loved Barbies as a girl but never had any like these," she wrote.
DuVernay has been vocal about her support for diversity in the entertainment industry, pledging last year that the film would have a cast "that looked like you, looked like the real world."
"A Wrinkle in Time" hits theaters in the United States on March 9, 2018.
[Ads /]
Editor's note: The Walt Disney Company is the parent company of Walt Disney Studios and this station.