Police said the home invasion and shooting happened in the Auburn Gresham neighborhood's 8000 block of South Carpenter Street just before 2 p.m.
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Two suspects entered the home, where two female victims and a male victim were inside, police said. The suspects battered the male victim and took property before fleeing on foot.
One of the suspects, a 31-year-old man, was shot in his body while fleeing, police said. He was transported to the University of Chicago Medical Center in critical condition.
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Officers took the other suspect, whose age was not immediately known, into custody.
The battered victim was transported to a local hospital in good condition for a minor injury, police said. No other injuries were reported.
Area Two detectives are investigating. Police did not immediately provide further information.