The tragic discovery was made in the 15400 block of Hamlin Avenue, in a subdivision of families and young children.
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"How does it not affect you? Being a mom, being a parent, nobody wants to see that," said Markham resident Karen Pokracki.
"I've lived here a long time, over 40 years, and nothing. Nothing like this ever happened like this," said Lorene Dykes, also Markham resident.
The fire started around 6 a.m. Monday morning. Police found the body of a small child was discovered inside the house.
The age, gender and cause of the child's death are unknown.
"It's devastating. It's terrible. I know different things happen in different people's neighborhoods, but you just wouldn't think it would happen in your own backyard," said Rebecca Orris, Markham resident.
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Neighbors say the house on Hamlin Avenue had been uninhabited for at least a year and a half.
For residents in the neighborhood on this holiday weekend, there's heartbreak and worry.
"Obviously the person who did this is still out there," said Orris. "Who is it? Am I safe? Can I sleep with my windows open tonight?"
Despite the house being empty for some time, neighbors say there haven't been any problems there in the past. The cause of the fire is also under investigation.