He was driving north on Interstate 55, near the Interstate 355 ramp, about 2:30 a.m. when the car went off the road and landed upside-down in a pond.
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A dive team removed one person from the vehicle, the man who was driving. He was pronounced dead on the scene, police said.
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A light pole and several pieces of guard rail were knocked down in the course of the crash.
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No identifying details have yet been provided about the man, and it's not clear how he lost control of the car, police said.
The ramp from northbound I-55 to I-355 is closed, while police investigate.