It's unclear exactly what led to the box truck tipping over, but video from the scene shows that it nearly rolled over the edge of the overpass.
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ABC13 Houston was live from the scene as Houston firefighters worked to rescue the driver from the truck.
It appeared firefighters used a harness to hoist the driver out of the passenger side window.
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Eventually, the ladder trucks retreated and an ambulance was seen leaving the scene. The driver's condition was unknown.
Some lanes of the I-45 HOV freeway, where the incident took place, were closed as officials worked to upright the truck.
No further information about what led to the crash was immediately available.