The shooting occurred in the 1700-block of South Newberry Avenue at about 2:35 a.m., police said.
Police said the boy was on a porch when someone inside a passing vehicle fired shots. The boy was shot in the head and pronounced dead at the scene.
The boy has been identified to the Cook County Medical Examiner's Office as Damien Santoyo of Chicago. Two other teens who were with Santoyo were not injured.
Police are investigating and no one is in custody.