Chicago police said a Chevy Trailblazer was driving south on Carpenter when it struck a Chevy Equinox head on at 86th Street, causing the Equinox to roll over into a yard.
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A 21-year-old man and two 17-year-old boys were taken to University of Chicago and Christ hospitals with non-life threatening injuries, police said, though they did not release further details about their condition.
The people driving the Trailblazer fled the scene, Chicago police said.
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No one is currently in custody. An investigation is ongoing.