The crash happened in the 400-block of Harlem Avenue at around 12:50 a.m., River Forest police said in a statement.
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Two people were pronounced dead at the scene.
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Two other people were taken to a hospital where they both died, police said.
One person out of the five in the car survived, police said.
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Police are in the process of identifying the occupants of the vehicle and making notifications to family members.
The cause of the crash is under investigation.