Police said a squad car was driving in the 11500-block of South Michigan Avenue just before 6:30 p.m. with its lights and sirens activated when it was struck by a Ford Explorer traveling westbound on 115th Street.
The impact caused the squad car to flip onto its side.
A spokesperson for the Chicago Fire Department said two police officers were taken to University of Chicago Hospital with non-life threatening injuries. Four others refused treatment at the scene.
The driver of the Explorer was cited for failure to yield to an emergency vehicle, driving without insurance and passing a vehicle on the right shoulder.
An investigation by the Major Accidents Unit is ongoing.