This happened at around 11:45 p.m. near River Road and Cullom, according to Schiller Park police.
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Video of the scene showed a white SUV with front-end damage in the southbound lanes. The rear-end of a silver car was ripped off and a third car was in the ditch.
The fatal victim was pronounced dead on the scene, police said. The two injured were transported to Advocate Lutheran General Hopsital with serious injuries.
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The area has remains closed while police investigate.
A cause remains under investigation.