The male driver of a white Honda sedan was traveling north in the 8100-block of Stony Island Avenue just after 12:45 a.m. when he lost control and struck a tree in Avalon Park, CPD said.
The male driver was pronounced dead on the scene, and has not been identified.
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A female passenger was also pronounced deceased on the scene. CPD did not immediately provide her identity or the ages of either victim.
The Major Accidents Unit is investigating the incident.
Emergency crews were no longer on the scene as of about 5:20 a.m.