Chopper7 was over the scene near S. Halsted St. and W. 63rd Street near Kennedy King College in the Englewood neighborhood around 5 p.m.
Chicago police said a driver ran a red light, hit another car and then hit two people who were walking in the area.
Four of the five adult victims were rushed to local hospitals in critical condition, according to a Chicago Fire Department spokesperson. The fifth adult is in fair condition.
Two children were also taken to University of Chicago Comer Children's Hospital in fair condition.