Two of the women were in a car that crashed and rolled over near Washington and Canal streets before 2 p.m., Chicago fire officials said. Chicago police said a car tried to make a left turn from a central lane, instigating the crash.
The two other women were walking on the sidewalk when they were struck by the car and thrown against a wall, officials said.
All four were taken to local hospitals, where two women have since stabilized and two others were listed in serious to critical condition, CFD said.
Further details were not immediately available.
The Sun-Times Media Wire contributed to this report.